It's a battle for global supremacy waged not between nations or religions, but... cats and dogs! Unknown to humans a war between the two has been fought for decades but there is currently a very fragile truce in place. However, when wacky Professor Brody (Jeff Goldblum) makes a discovery that could tip the age-old battle between the rival domestic pet species, Lou (voiced by Tobey Maguire), a feisty young beagle puppy, must act to prevent the felines lead by Mr Tinkles (Sean Hayes), a white persian cat, from achieving world domination.