The band of ghost busters are back to save the universe. Having been put out of commission due to a judicial court order the fearless four pull out all psychic stops to put an end to a demonic river of slime and rescue Dana Barrett (Sigourney Weaver) and her child. In order to achieve this they must convince New York that all the citys negative energy is feeding the evil spirits in the river so the citys residents need to resist all negativity.